A study from Augusta University’s Medical College of Georgia has linked high-dose CBD to multiple benefits associated with early-onset familial Alzheimer’s disease. The positive results included improved cognition and restored function in those proteins responsible for clearing plaque from the brain. In addition, the CBD was found to reduce levels of a protein linked with the excessive inflammation found in Alzheimer’s patients.
Alzheimer’s disease is a rapidly growing public health threat and is expected to accelerate as a major problem worldwide. As populations live to older and older ages Alzheimer’s becomes a growing threat. Alzheimer’s disease has been traced to a build-up of beta-amyloid plaques along with other ‘debris’ in the brains of its sufferers. Some of the reasons for contracting the disease may be a result of genetics, lifestyle factors, among various other causes.
There are two proteins in particular that are believed to play key roles in clearing the brain of the plaque and dead cells. These proteins have been isolated as IL-33 and TREM2 and each are known to exist at lower levels in the case of Alzheimer’s disease. The Augusta University study has determined that high-dose CBD may normalize the level of IL-33 protein in the brains of Alzheimer’s patients while reducing levels of the inflammation-promoting IL-6 protein. The CBD was linked to benefits associated with TREM2, which is found in lower levels in Alzheimer’s patients. Overall, the CBD protocol was linked to a sevenfold and tenfold increase in IL-33 and TREM2 protein levels — at least in mice. Beyond that, the mice were found to exhibit improvements in their mobility when given the CBD.
Additional research is necessary and this includes research to determine the ideal dosage while evaluating the effects on CBD when administered in the early stages of early-onset Alzheimer’s disease. The findings pave the way for a potential future novel treatment for Alzheimer’s disease that may help address the underlying changes that lead to the disease’s development.
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